[00:00:00] Speaker A: Patriot is WWTC, Minneapolis St. Paul FM.
[00:00:03] Speaker B: One hundred seven point five k two hundred ninety eight Co. Minneapolis intelligent Radio.
[00:00:11] Speaker C: Minnesota News, I'm Baba Agnew in Washington. Former President Trump says he was not impressed by Kamala Harris's interview this week.
[00:00:18] Speaker A: You think she's gonna be able to handle President Xi?
[00:00:21] Speaker C: I don't know. I don't think so. China, North Korea, Russia? I don't know. The former president spoke on Friday in Johnstown, Pennsylvania. US Senator Tom Cotton of Arkansas says the reported tussle between a Trump campaign staffer and an official at Arlington National Cemetery this week is much ado about nothing.
[00:00:40] Speaker A: It seems to me like they did everything to try to prevent President Trump from going with the families of the fallen to Arlington National Cemetery because they didn't want to highlight Joe Biden and Kamala Harris's disgraceful failures in Afghanistan.
[00:00:56] Speaker C: Mister Trump had been invited to Arlington by family members of some of those killed three years ago during the botch pullout from Afghanistan. Senator Cotton spoke this week with the Salem radio network. This is SRN News.
[00:01:08] Speaker B: Charlie Kirk sees the impact he has on America.
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[00:01:51] Speaker B: In my 30 plus years, I've never.
[00:01:53] Speaker A: Seen such a concerted attempt to silence our efforts.
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[email protected]. dot did you know I could suck my thumb before I was misses born?
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[00:02:33] Speaker A: We all started small child life across America to build more people. Have you filed for disability benefits but were denied by the Social Security Administration? Or do you need to apply and are overwhelmed with paperwork? Are you between the ages of 50 and 63 and can no longer work because of an illness or injury. Thousands of hardworking Americans are in your situation. They file for disability benefits and are unnecessarily denied their much needed benefit check. Call now for a no obligation free evaluation. We can help you nearly double your chances of approval and get your benefit checks faster. We understand the physical, emotional and financial impact. We'll share our insider expertise and help you get your disability claim filed and paid immediately. There is a time limit to apply, so call right now. Operators are standing by to help you. 802 961553 802 961553 802 96156 that's 802 96153.
[00:03:39] Speaker E: Well, summer is upon us and the weather is beautiful. Everyone has a favorite outdoor activity, golf, bike riding, bird watching, long walks. Ask 100 people and you'll get 100 answers. But if everyday aches and pains are keeping you on the sidelines, I have one answer. Relief factor. Relief factor is a 100% drug free daily supplement that helps your body fight pain naturally. Developed by doctors, relief actor uses a unique formula of natural ingredients. It doesn't just mask pain, it helps reduce or even eliminate it. Wherever you're hurting back, neck, joints or muscles, in three weeks or less, you'll start to feel the difference all day, every day. So whatever you like to do, swimming, pickleball, hanging out in the garden, relief factor can help you feel good again and let you enjoy all your favorite outdoor activities all summer long. Relief factor.com 1804 Relief 1804 735433 fight pain naturally with the relief factor when.
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[00:05:10] Speaker B: Pre recorded and the views expressed do not necessarily represent those of this station or its management.
[00:05:15] Speaker A: This is open your eyes radio with doctor Kerry Gelb.
[00:05:19] Speaker C: Good morning. I'm Doctor Kerry Gelb, and welcome to 1280 on open your eyes radio. Please listen as I discuss the newest information in the world of health, nutrition and sports every Saturday morning 06:00 a.m. central time on AM 1280. The Patriot. Also, please share your thoughts by emailing
[email protected] dot that's drkerrygelb mail.com and visit my new website, wellness 1000 280 dot where we have all guest links, wellness 1280 info and previous shows. Wellness is taking over the Patriot Airways. For the next hour, sit back and enjoy my conversation with Doctor Kyle Joliette. Part two for those who heard last week, and if you didn't, go back and listen. Doctor Gillette is a Kansas physician who specializes in hormone pathology and he is known for his expertise in helping patients with hard to treat and hard to diagnose and unusual medical conditions. His practice includes preventive and integrative medicine, aesthetics, sports medicine, hormone optimization, obstetrics and infertility. And be sure to subscribe to his podcast, the Gillette Health podcast. Doctor Kyle, thank you for coming back this week. And when we left off last week, we were talking about repurposed drugs and I asked you about erythromycin and you said there were better options for autophagy and if you could continue with that, with some of the better options that may be non prescription even.
[00:06:53] Speaker A: Yeah, the first thing that I mentioned was being in a caloric deficit or even decreasing carbohydrate in the diet to some degree. I'm not a huge proponent of intermittent fasting, but I do like the concept of time restricted feeding for those that may want a better autophagy benefit. For example, a patient that has a strong family history of cancer, but maybe they don't have a brachi mutation or lynch syndrome where they would want to go with something more aggressive like rapamycin or more aggressive like dasatinib or quercetin. So there's a lot of other options in that regard. However, next I mentioned psyllium, which might not make a lot of sense, but there is a strong link between the health of the gut and the health of mitochondria, not just throughout the body, but also in the brain itself. We have a saying in functional medicine, leaky gut, leaky brain, talking about the blood brain barrier. And then psyllium can also help and other types of fiber, too. Um, you know, there's, there's a lot of them, um, to name some of them, paleo fiber. Fiber, fiber mend. Um, lots of different, uh, you know, I call big supplement companies big functional, then I call big drug companies big pharma. So you have your big pharma options. You have your big functional options, and for the right patient, there's a reasonable strategy for, for both of them. But more often than not, I have people track the actual fiber they eat throughout the week. And if males don't average 40 grams of fiber per day, and if females don't average 30 grams, I do think it's reasonable to supplement some.
[00:08:23] Speaker C: Are you a fan of urolithin a or spermidine?
[00:08:26] Speaker A: In some cases I use them, but I don't use them as senolytics. So for patients that have diets that are very low in fruits and vegetables, I do use urolithin a and physetin and lots of other things that you can otherwise get from fruits and vegetables. If you study different polyphenol blends. Again, these big functional companies almost all have a polyphenol blend. 510 years ago, it was resveratrol, and now, after that's been studied more, it's fallen out of favor. But I don't think resveratrol is actually a bad or unhelpful polyphenol. I just think it's one thing that's going to add to the antioxidant potential of the body and another thing that affects the gut microbiome. Things like curcumin and quercetin, I don't think have to be bioavailable or absorbed at all, which means that your body absorbs them from the gut. I think they're helpful just for their effect on the gut microbiome. But if you look at people who just add a wide variety of fruits and vegetables into the diet, strawberries, blueberries, that way you don't have to supplement with your physetin and your anthracyanins and your blueberry extract and your nootropic. I think that's the best way to go about it. But again, for some patients, let's say they're on a ketogenic diet because of a specific health reason. Epilepsy would be one, a benign brain tumor would be another one. Then supplementing with things like spermidine and urolithin a can be reasonable.
[00:09:57] Speaker C: And how about come astartin, my cartis, as a health strategy? I know it's actually, I think, a banned substance in some, you know, athletics, but it increases vasodilation, increases blood oxygen supply. Tell me what your opinion of these arbs are.
[00:10:17] Speaker A: Yeah, so telmasartan is interesting because it is an angiotensin receptor blocker, and arbs don't tend to have near the cough risk. For all intents and purposes, ACE inhibitors are not used very often because they increase something called bradykinin, which can give you a cough, which is not super common, but it definitely happens. And arbs are blocking that angiotensin receptor instead, so they can decrease blood pressure. So it's great for patients that have congestive heart disease and then also that have high blood pressure. And it's also good for patients that have high blood pressure and are on HRT and who have sleep apnea too, because that's usually the mechanism of why blood pressure increases. However, if you look at correlation studies, again, not causation, there does seem to be a correlation with patients who are on arbs and they get cancer slightly more often. It's probably because of other comorbidities, which basically means patients who tend to start blood pressure meds like arbs, probably have a higher baseline risk of cancer, but we don't know that for sure. So I certainly don't think that arbs are medications with zero side effects. Also, they do increase potassium in the blood, so monitoring with labs is very important. But as I choose blood pressure medications or as I choose medications for kidney health or heart health, of which Tilma Sartin can help prevent the progression of both, it is one of my more favorite options. It is also a weak ppar delta. PPAR works on.
It's basically something that helps shunt energy into the mitochondria. And it's also studied for fatty liver disease. There used to be a PpAR delta agonist called Carterene, which was GW 501516 or 5156. Both are accepted names, which was studied by GlaxoSmithKline for several things, including metabolic syndrome. And a rat study in rats that tend to get cancer showed that it made them get cancer even faster, which kind of makes sense, because if you give a rat growth hormone, then it grows that cancer even faster. And even if you give rats high doses of NMN or NR or NAD, which are ATP precursors, they also grow their cancer faster.
They're now studying a new substance that is a pan PPAR agonist. So it's alpha, gamma and delta, although they've renamed delta beta to make it more tricky. So you'll notice, and I do think that that one will get approval for fatty liver disease and metabolic syndrome, both.
[00:12:54] Speaker C: And any repurposed drugs that you use on a regular basis that you might mention.
[00:13:01] Speaker A: Yeah, I suppose the most common one would probably be testosterone in perimenopausal and menopausal females. Again, there's still no. In the United States, there's still no FDA approved testosterone for females.
I do like the subcutaneous injections of testosterone cypionate or testosterone enanthate, because the creams actually convert to DHT more and most women do not want a lot of DHT because if they tend to be sensitive to androgens, then they have masculinization side effects, which we call virilization.
[00:13:32] Speaker C: They look like me soon.
[00:13:34] Speaker A: Yeah, pretty common. Usually they don't notice because they one, they feel great, but a lot of times if they get a pellet or use a cream, it is just dose too high. And obviously, women can take five alpha reductase inhibitors like dutasteride as well, especially if they have no chance of getting pregnant.
But that's probably the most common repurposed drug. There's many other ones that I use as well. If there's a patient that has some coronary artery disease, but also a high lipoprotein, then often I use PCSK nine inhibitors. Then I often use ezetimibe in patients who have not had a heart attack or a stroke. That way I don't have to escalate them to statin therapy as often.
[00:14:17] Speaker C: That's great stuff. So we're going to get into hormones in the next segment, and I want to dive deep into testosterone. And what are some of the symptoms of low testosterone? Who should be on testosterone? I want to talk about pellets. I want to talk about gels. So, as we're finishing up, Kyle, people want to know how you got into this type of medicine in the last few days.
[00:14:42] Speaker A: Yeah, my dad's a family practice physician as well. We both practiced Obe for quite some time. We both delivered hundreds of babies, and we still practice together here at Gillette Health. But I wanted to do a good job taking care of common pathologies like hormone pathologies and obesity.
[00:14:57] Speaker C: This is doctor Kellerie Gell for open your eyes radio. We'll be back with doctor Kyle Jewett in just a moment.
[00:15:09] Speaker D: I went to the eye doctor the other day with my daughter Maggie. I was shocked when the doctor told me that my daughter was already becoming nearsighted. It turns out that this problem affects more than 40% of Americans. My eye doctor thinks this disease is getting worse. Perhaps it's getting worse because of kids prolonged time spent playing with smartphones. Or maybe because kids now spend less time outside my genetics. Probably aren't helping her a whole lot being nearsighted myself. But the good news is that the doctor told me about a new FDA approved product called Mysite. This specific one day contact lens is already worn by thousands of children in the US. It is proven to slow down the progression of nearsightedness. And best of all, Maggie loves these contact lenses. The doctor taught her how to use them. Now it is so exciting to see her have even more success in the classroom and when she plays sports. I recommend you visit openyoureyesradio.com to find an eye doctor that specializes in this treatment program. Learn
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[00:17:09] Speaker D: Went to the eye doctor the other day with my daughter Maggie. I was shocked when the doctor told me that my daughter was already becoming nurse sighted. It turns out that this problem affects more than 40% of Americans. My eye doctor thinks this disease is getting worse. Perhaps it's getting worse because of kids prolonged time spent playing with smartphones, or maybe because kids now spend less time outside. My genetics probably aren't helping her a whole lot, being nearsighted myself. But the good news is that the doctor told me about a new FDA approved product called Mysite. This specific one day contact lens is already worn by thousands of children in the US. It has proven to slow down the progression of nearsightedness. And best of all, Maggie loves these contact lenses. The doctor taught her how to use them. Now it is so exciting to see her have even more success in the classroom and when she plays sports. I recommend you visit openyoureyesradio.com to find an eye doctor that specializes in this treatment program. Learn
[email protected] dot.
[00:18:13] Speaker C: We'Re back with doctor Kyle Gillette website gillette health.com if you need to make an appointment. If you want to make an appointment,
[email protected] at g I l l E T t his podcast Gillette health is his podcast. His instagram is Kyle Gillettemd. So, Doctor Gillette, thank you for joining us for the second segment here. And so tell us, for the people out there, what is a hormone?
[00:18:41] Speaker A: Yeah. Hormones are the signaling molecules that connect one organ system to another. That's what an endocrine hormone is. It connects one organ system, for example, the brain, to another, for example, the thyroid or the gonads. There's also autocrine and paracrine, hormones that are talking to organ systems that are very close to each other or even the same organ.
[00:19:02] Speaker C: So you have six pillars of how to optimize hormones. Can you review those?
[00:19:07] Speaker A: Yeah. So they start as you would think they would start. They start with diet, exercise, and sleep. And those are the three most powerful pillars. But in general, if you're trying to naturally optimize your hormone status, which you should do regardless of your age or if you're male or female, you can even do this. You know that. You know, babies, I deliver the prenatal care that I give. I'm optimizing the hormones of both the mother and the child at the same time. But the last three are ss for alliteration, it's sunlight and then spirit and then stress. Sunlight just means we're meant to be outside. We're in artificial environments right now, but it's great to be in a non artificial environment. I know that all the time. You're talking about the benefits of looking far in the distance for eyesight benefit and prevention of degenerating eyesight. I know that my preventive medicine colleague, doctor Taylor Martin, talks about how losing hearing and losing eyesight are two huge independent risk factors for dementia. So there's certainly hormone benefit to that as well.
Partly just getting on your normal nocturnal diurnal cycle, which basically means your body's organs that produce hormones know it's night and day, and then stress.
You want to progressive overload stress. You don't want a zero stress life. You want a little bit of stress, but something that you can handle. And I think that that's one of the things that as a father who's raising multiple children, I think that's one thing that's very difficult. I was homeschooled and my brothers were as well. And I think that that helped us acclimate to various life stressors that perhaps in an artificial school environment, that's not done as well.
Just like you're lifting weights in the gym and it can feel good to get that weight lifted. That's really heavy. I think the same thing can be done with stress. And when you're overly stressed, it does have an effect on your hormone profile via multiples. And then past that, spiritual health again, taking care of the body, the mind, and the soul. I'm a Christian. Not everybody else has to be. But on Maslow's hierarchy of needs, at the end of the day, there's going to be that self actualization piece.
Most physicians that have taken care of palliative care patients know that if there's someone that has a metaphysical crisis near the end of their life, that can tank all the rest of their health as well, and that can really happen at any time. I think that's why people have midlife crises or quarter life crises or whatever they're calling it these days.
Anyway, past that, I've now added social health as a pillar as well. I was on a podcast called Rich Roll podcast, and he said, with a pandemic and all those things that happen, we need to add social health.
[00:21:47] Speaker C: So we have right, right now, you mentioned diet. What do you feel is the best diet? There's all these vegan diets, from vegan to carnivore and everything in between. What do you think?
[00:22:02] Speaker A: Yeah, a mostly whole food diet that you can adhere to, that you like. So there's not really anything that's a perfect diet, partly because a different diet for one person is not going to be as ideal for another. For example, if there's someone that is exercising much more often that wants to perform at a high level, doing high intensity cardiovascular exercise or aerobic exercise, they're probably going to want to incorporate more carbohydrates. So as I do local functional fitness or hybrid fitness events, or a lot of running, then I will increase the carbohydrates in my diet for some conditions.
[00:22:42] Speaker C: Are you talking about just fruits and vegetables, or are you talking grains also?
[00:22:46] Speaker A: Yeah, I'm not against grains. Of course, people with celiac disease should not eat gluten, but I'm certainly not against grains.
It really depends on the person, though. There's no one perfect diet. You want to adhere to it, ideally at least 90% of the time, and you want to minimize processed foods. And you especially want to minimize ultra processed foods.
[00:23:07] Speaker C: You know, I want to ask you about this. I have a friend who, when he has a pretty healthy diet, you know, he eats just like you said. He doesn't eat a lot of processed food, doesn't eat a lot of processed oils. He eats some meat, mostly vegetables, and his tmao level, he's a lot of fish. His Tmao level was very high, and he's. He's very worried about cardiovascular disease, but he goes, I don't know what else to do to lower it.
Do you think Tmao is a dangerous marker for cardiovascular disease, or do you think it's more for gut?
[00:23:42] Speaker A: Yeah, I think it's more indicative of gut health. TMAO is a potential or theoretic carcinogen. So perhaps if it's really high for a long period of time, then it could be related to cancer risk. We don't know that for sure, and I guess you could make a similar argument for cardiovascular disease, but I think it's more of a correlation. If you have high tmAo, it tells you something about your gut microbiome, because your gut microbiome converts things like choline, which is found in egg yolks, which is an acetylcholine precursor, which is a neurotransmitter.
You want to have good choline in the diet, especially if you're pregnant and you're growing a fetus that has brain. That's when it's most important.
Then you also want to have good sources of any amino acids in the diet. Carnitine is a peptide that has two amino acids that can also convert into tmao. However, if you have a healthy gut microbiome, these tend not to convert to tmao. So some people take berberine supplements, which does not have to be systemically absorbed to help control tmao conversion. Some people will take allicin supplements, which is known as allicillin, kind of a pawn off penicillin because it alters the gut microbiome as well. And these things can help. But even things like prebiotic or dietary fibers can also help. I know that one of my friends, his name is Derek, he has a YouTube channel called more plates, more dates.
He and also myself have seen people, including ourselves, that have taken very high levels of carnitine and choline, which you would think would both convert to tmao. And without any supplements, we still have very low tmao levels, likely because of the composition of the gut microbiome.
[00:25:24] Speaker C: And you mentioned before, creatine. Is creatine okay for kids to take also or teenagers that are trying to build muscle?
[00:25:34] Speaker A: Yeah. The American Academy of Pediatrics has a statement that right now they do not recommend kids. They do not recommend for creatine supplementation. But it does appear safe. If you eat a kilogram of pork or a kilogram of chicken, then you do get something like, you get more than a gram of creatine in that. So that's obviously a lot of meat that you need to be eating. But if you eat a lot of meat in the diet, then you do eat a lot of creatine.
In specific cases, creatine can make certain blood markers look higher. And if you start creatinine and you start working out and you go to the gym and you get your blood drawn right after, its common for your creatinine, which is a sign of kidney dysfunction, to be high. So if youre on creatine and youre exercising a lot and you have a lot of muscle mass compared to the average american, you might want to do just very easy workouts for three days before your labs. That way your creatinine can look more normal or you can pause your creatine supplement for three days before. But it is healthy for the kidneys and its healthy for the kidneys for kids as well.
I generally don't recommend it until age twelve or so, but individuals between twelve and 18 should obviously talk to their doctors for their specific recommendation.
[00:26:47] Speaker C: Do you think because it increases water into the muscles and it actually makes you stronger that you have a greater risk of ripping tendons or ligaments?
[00:26:57] Speaker A: I don't think it's a significant risk. I do think that if you take creatine you're at very high risk of exercising frequently because you're probably taking creatine because you've started an exercise regimen. It takes about six weeks to significantly hypertrophy most muscles. And in general it takes about six months to significant hypertrophy and remodel and strengthen the tendons. So for this, um, if it's your first six months doing something, I recommend mostly just going through the motions. For example, if you start olympic weightlifting or crossfit or any other activity, that's higher risk than slow, eccentric and concentric or even isometric exercises. Isometric exercises are great for tendon health, then that can, that can be a good way to offset tendon injury risk for any sort of supplement. We know that all lipid lowering therapies and or quote unquote cholesterol medicines put you at risk of tendon injury or even tendon rupture, except for ezetimibe, which is a cholesterol absorption inhibitor.
[00:28:00] Speaker C: Why do statins increase the risk of Achilles tendinitis or tendinosis? Why does it do that?
[00:28:07] Speaker A: Yeah, there's a couple theories. One is they do seem to affect Coq ten levels. Coq ten is what converts nad energy to ATP energy. And then another reason is they do deplete vitamin K two. Vitamin K two is what shunts calcium into things like bones, tendons and muscles for normal contraction. K two is a very important thing to basically tell your body where to put the calcium rather than vitamin D, just telling it to absorb it.
Another reason could be that the mitochondria do not have as much energy independently of coq ten. So it's not well known, but there's a lot of case studies and correlations. And if you look at the newest lipidorine therapy, bempidoic acid, 0.4%, I believe, of people in their phase three clinical trial where it got FDA approval, actually had an Achilles tendon rupture.
[00:29:08] Speaker C: Now, before we're coming up to the brain, before you mentioned the NAD precursors, increasing the risk of cancer, NAD itself, does that increase taking, that increase the risk of cancer? If you're taking it iv or you're taking precursors, I guess you mentioned it before. Tell me about NAD and cancer.
[00:29:25] Speaker A: Yeah, this risk is only preclinical. Preclinical is the medical way to say animal study. So in animal studies, it increases the risk of cancer. And about 2% of animal studies convert to being clinically significant humans. That being said, the theoretical risk is there, and it would be there for actually anything that increases ATP to an above physiologic amount. So patients who have a type of muscle ache called myalgia because of depletion of this NAD, we know.
[00:29:58] Speaker C: Hold that thought. We'll be back after the break.
[00:30:09] Speaker D: I went to the eye doctor the other day with my daughter Maggie. I was shocked when the doctor told me that my daughter was already becoming nurse sighted. It turns out that this problem affects more than 40% of Americans. My eye doctor thinks this disease is getting worse. Perhaps it's getting worse because of kids prolonged time spent playing with smartphones, or maybe because kids now spend less time outside my genetics probably aren't helping her a whole lot, being nearsighted myself. But the good news is that the doctor told me about a new FDA approved product called Mysite. This specific one day contact lens is already worn by thousands of children in the US. It has proven to slow down the progression of nearsightedness. And best of all, Maggie loves these contact lenses. The doctor taught her how to use them. Now it is so exciting to see her have even more success in the classroom and when she plays sports. I recommend you visit openyoureyesradio.com to find an eye doctor that specializes in this treatment program. Learn
[email protected] dot well, summer is upon.
[00:31:11] Speaker E: Us and the weather is beautiful. Everyone has a favorite outdoor activity. Golf, bike riding, bird watching, long walks. Ask 100 people and youll get 100 answers. But if everyday aches and pains are keeping you on the sidelines, I have one answer. Relief factor. Relief factor is a 100% drug free daily supplement that helps your body fight pain naturally. Developed by doctors, relief factor uses a unique formula of natural ingredients. It doesnt just mask pain, it helps reduce or even eliminate it. Wherever you're hurting back, neck, joints or muscles, in three weeks or less you'll start to feel the difference all day, every day. So whatever you like to do, swimming, pickleball, hanging out in the garden, relief factor can help you feel good again and let you enjoy all your favorite outdoor activities all summer long. Relief factor.com 1804 relief 1804 735433 fight pain naturally with a relief factor I.
[00:32:09] Speaker D: Went to the eye doctor the other day with my daughter Maggie. I was shocked when the doctor told me that my daughter was already becoming nearsighted. It turns out that this problem affects more than 40% of Americans. My eye doctor thinks this disease is getting worse. Perhaps it's getting worse because of kids prolonged time spent playing with smartphones, or maybe because kids now spend less time outside. My genetics probably aren't helping her a whole lot being nearsighted myself. But the good news is that the doctor told me about a new FDA approved product called Mysite. This specific one day contact lens is already worn by thousands of children in the US. It is proven to slow down the progression of nearsightedness. And best of all, Maggie loves these contact lenses. The doctor taught her how to use them. Now it is so exciting to see her have even more success in the classroom and when she plays sports. I recommend you visit openyoureyesradio.com to find an eye doctor that specializes in this treatment program. Learn
[email protected] dot.
[00:33:12] Speaker C: I'm back with doctor Kyle Gillette website gillette health.com, his Instagram Kyle Gillettemd and his podcast Gillette Health podcast. Please listen. Doctor Gillette, before the break I was asking about Nad. Does it increase your risk of cancer or its precursors? And you said in animals maybe?
[00:33:34] Speaker A: Yeah, sort of. I think most likely it will increase your risk of growing a cancer, but I don't think it's going to cause a new cancer and it is a dose dependent effect.
[00:33:44] Speaker C: And collagen. What do you think about taking collagen for kids, you know, kid athletes over twelve.
What do you think? Collagen, good or bad, is it worth putting in the smoothie?
[00:33:56] Speaker A: I don't think it's particularly helpful for hair, skin or nails for patients that don't eat a lot of meat on the bone. I do think that collagen is more helpful depending on the amino acid profile that you consume. So there's a lot of amino acids like glycine and proline. And some patients, actually, including myself, tend to pee out glycine and proline more than other amino acids, which are protein building blocks. So consuming collagen more often can be helpful, even from a bone density standpoint.
So if you have a family history of osteoporosis and you're trying to optimize your bone density, collagen can be reasonable for that purpose if you tend to pee out glycine and proline. A lot of people take glycine for sleep benefit because it's also kind of an inhibitory neurotransmitter. And collagen has a whole bunch of glycine. So if you're already supplementing with glycine for sleep, but you don't like collagen because the studies on hair, skin and nails aren't great compared to placebo, then it's probably cheaper and tastier to just take a collagen supplement. There's also studies that it increases tendon thickness and springiness by up to 20%. So I do think it's reasonable to take, but it's not a replacement for high leucine and methionine content in the diet. For example, eating meat.
[00:35:10] Speaker C: Now, melatonin helps us fall asleep, but what supplements help us stay asleep? Would that be glycine?
[00:35:17] Speaker A: Yeah, theoretically, glycine can. Gaba can also help you stay asleep. But GABA is another inhibitor or neurotransmitter. Kind of like glycine has a pretty fast half life. So if you're thinking about anxiolytic medications or medications for insomnia, like a benzos and non benzos, examples of that would be like alprazolam, that is kind of a tranquilizer. So that's too much stainless leap in most cases, but it can be useful for things like panic disorders and then things like ambien.
That is another kind of gaba agonist. You can take bio identical Gaba, which is often a better form, but it's worn off by the time that you stay asleep. Some patients that wake up at, say, 02:00 a.m. 03:00 a.m. 04:00 a.m. instead of taking.
There used to be a med called intermezzo that they would take, which, again, is probably too powerful. That hit GAba, that agonized GAba, which means activates it. Then they can take some liposomal gaba or liposomal l theanine so that it can be absorbed faster than taking a capsule.
That can help. But other than that, having a good sleep cycle is going to help you stay asleep the most. The rule I use is ten, three, two. No caffeine so that your adenosine signaling knows when to activate, not activate. You can dump it, if you will. 3 hours and 2 hours. No vigorous exercise or a huge meal. 1 hour. No bright white or blue light. Um, you're more of an expert on that. So I don't know if you tell people 1 hour or 2 hours if you wear blue blockers just the last hour or two of the day.
[00:36:57] Speaker C: Uh huh. Yeah. I mean, blue filtering lenses, certainly.
[00:37:02] Speaker A: So, blue filtering lenses, if you do that, just the end part of the day and certainly not in the morning, and then zero snooze and ideally, zero variation in the time you go to sleep and the time that you wake up.
[00:37:14] Speaker C: So the people wake up sometimes in the middle of the night because their blood sugar drops.
[00:37:19] Speaker A: That can also happen. That can be called the dawn phenomenon. So, for people that don't have diabetes, that are on glucose lowering therapies, often they just want to take them in the morning and not the evening.
[00:37:30] Speaker C: And how about people that wake up in the middle of the night, they can't go back to sleep, and then they eat something little like a bite of banana because their blood sugar went down, and that helps them go back to sleep. How bad is that? Or how is that? Okay, Evan?
[00:37:44] Speaker A: Yeah, it's certainly not ideal. So, with dawn phenomenon, your blood sugar drops, then you release glucagon, and then because of glucagon, your sugar spikes, actually. So eating something is a different way to spike your sugar without the glucagon release, hopefully. Um, but that alters, uh, two areas of your hypothalamus. You have orexigenic signaling and anorexogenic signaling. With orexigenic signaling, you're hungry, awake, and somewhat agitated or hangry. Um, and then, uh, with anorexia signaling, you're sleepy and you're not hungry. So this new class called doras, or dual orexin receptor antagonists, turns off that hungry, angry, and awake signal, similar to how eating some carbs or eating a little bit of food would. So it's not terrible. But ideally if you do that, it's just a very small amount of something healthy before you go to bed initially, and then you wouldn't have to wake up at all.
[00:38:37] Speaker C: And are you a fan of Taurine?
[00:38:38] Speaker A: I do like Taurine, yeah. I think that it helps a lot. In some cases, I take two to 3 grams a day to help with excess muscle cramps or spasms.
[00:38:48] Speaker C: And back to just a second, because you did ask me about the blue filtering lenses. Yeah, it's definitely at night, and you know, it's definitely helpful if you're looking at it. Of course, I'm not using them now, but if you're looking at a computer, it definitely helps.
And most not in everybody, but it definitely helps in most people. And I had somebody on the podcast from RA optics, and that's usually a good place to get those glasses if you're looking for blue filtering lenses. So let's talk about testosterone again.
Tell us what if you have low testosterone, what will some of the symptoms be?
[00:39:26] Speaker A: In a man, this is highly variable, but in both males and females, you have, what's more of your classic symptoms, lower libido, lower drive, and also effort. Not feeling as good, and not necessarily just in tune with your workout, but often your workouts don't feel as good, your recovery is not as fast. Testosterone is also dopaminergic. So things that are dopaminergic tend to help with focus and tend to help with drive. In addition, some symptoms could just be increased body fat and decreased lean body mass. Not necessarily a reason to jump to hormone replacement, but certainly a reason to at least try natural hormone optimization and get some labs to see if that's one of the main contributors of body.
[00:40:11] Speaker C: Composition changes and testosterone non sexual functions. What are some of those?
[00:40:17] Speaker A: Yeah, so I guess you could say the dopaminergic function is somewhat sexual, but all androgens are dopaminergic. So dopamine is the motivation and to some degree focus hormone, so it can improve the cognitive drive. So there's actually some entrepreneurs that have relatively low testosterone. Maybe they're in between starting, but they want more of that drive to get their startup or their entrepreneurial business going that they do much better with a little bit of extra testosterone. Theres an interesting correlation between synthetic hormone replacement, which is what I call oral contraceptives. Females that start oral contraceptives, and females that start estrogen plus progesterone without testosterone often decrease their testosterone levels by about half. And often they have a decline in libido. Often they have body composition changes, and often they are actually more likely to start antidepressant medications.
That's why things like DHEA, which is a weak androgen, and even testosterone, have been studied to take in conjunction with synthetic estrogens and synthetic progesterones to even out the balance between the three.
[00:41:30] Speaker C: And it makes red blood cells. Testosterone, is that correct?
[00:41:33] Speaker A: Yeah. Androgens will increase something called erythropoietin, or EPO, which increases red blood cell production. Androgens also stimulate an area of the brain, kind of in the front of the brain, that makes your sympathetic nervous system, which is fight or flight, more active. And this will cause your breathing cycle to be slightly different. This will cause your REM sleep to be slightly more aggressive. So you might have more hardcore dreams and you also might have worse sleep apnea, even if there's no changes to the neck itself.
[00:42:08] Speaker C: And what does somebody look like that has low testosterone? They come in, are they pale? Are they, I mean, obviously they could have dry, in my case. Are they typically obese?
What do they look like? What are the physical signs of someone that has low testosterone?
[00:42:28] Speaker A: Yeah, it can be widely variable. So if you're talking about low total testosterone, a lot of the studies on testosterone that show how levels change only check a total testosterone. There's a protein called shbg. And the higher your shbg, sex hormone binding globulin, the more you preserve testosterone. So if you have prediabetes or diabetes or insulin resistance, shbg is often very low. Or if you just eat a lot of carbs, shbg is often low.
So most people who have a higher body fat percentage, their total testosterone is low, not because they dont produce enough, but because its metabolized so fast. They have a high free testosterone, but a low total. So that phenotype is certainly different than a patient that has, lets say a pituitary adenoma, which are rare but not super rare, where they just have low, low lh and low fsh and not enough signal from the brain to the testes.
[00:43:29] Speaker C: And what's normal total testosterone? I mean they say 300 to 1000. But what do you think is optimal, what most people feel good on and what is optimal? Free testosterone.
[00:43:42] Speaker A: Yeah, I consider so for patients that are not on five alpha reductase inhibitors, like dutasteride. Dutasteride is going to lower your DHT and raise testosterone. But for patients that are not on those normals, between about 401,000 although the normal range is usually 264 to about 1000, and optimal is between about 551,000. But if you have a total testosterone of 550, you probably want a DHT that's a little bit higher. So you can't have a total t of 550 and a low DHT and be optimal.
[00:44:15] Speaker C: And if your testosterone is low, is it associated with depression, osteoporosis, anemia, obesity, diabetes? Would that be a correct statement?
[00:44:28] Speaker A: Yeah, it's associated with all of them. And I think that's actually one of the main reasons why for men that are truly hypogonadal, which means they have low testosterone, and also for women that do estrogen replacement therapy, they tend to have less heart disease, not because the testosterone is replaced, but because the estrogen is replaced.
[00:44:44] Speaker C: And people that have low testosterone, I mean, there's been studies that show they don't live as long. Is that correct?
[00:44:50] Speaker A: Yeah. Again, causation and correlation, but certainly their quality of life is better if they replace the testosterone.
[00:44:56] Speaker C: We'll be back after the break. This is doctor Kerry Dell for open your eyes radio.
[00:45:08] Speaker D: I went to the eye doctor the other day with my daughter Maggie. I was shocked when the doctor told me that my daughter was already becoming nurse sighted. It turns out that this problem affects more than 40% of Americans. My eye doctor thinks this disease is getting worse. Perhaps it's getting worse because of kids prolonged time spent playing with smartphones, or maybe because kids now spend less time outside. My genetics probably aren't helping her a whole lot, being nearsighted myself. But the good news is that the doctor told me about a new FDA approved product called Mysite. This specific one day contact lens is already worn by thousands of children in the US. It is proven to slow down the progression of nearsightedness. And best of all, Maggie loves these contact lenses. The doctor taught her how to use them. Now it is so exciting to see her have even more success in the classroom and when she plays sports. I recommend you visit openyoureyesradio.com to find an eye doctor that specializes in this treatment program. Learn
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[00:47:09] Speaker D: Eye doctor the other day with my daughter Maggie. I was shocked when the doctor told me that my daughter was already becoming nearsighted. It turns out that this problem affects more than 40% of Americans. My eye doctor thinks this disease is getting worse. Perhaps it's getting worse because of kids prolonged time spent playing with smartphones, or maybe because kids now spend less time outside. My genetics probably aren't helping her a whole lot, being nearsighted myself. But the good news is that the doctor told me about a new FDA approved product called Mysite. This specific one day contact lens is already worn by thousands of children in the US. It is proven to slow down the progression of nearsightedness. And best of all, Maggie loves these contact lenses. The doctor taught her how to use them. Now it is so exciting to see her have even more success in the classroom and when she plays sports. I recommend you visit openyoureyesradio.com to find an eye doctor that specializes in this treatment program. Learn
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[00:48:12] Speaker C: We'Re back with doctor Kyle Joliette website, joliethealth.com. that's Gillett. And if you want to make an appointment in his office, it's officeealth.com dot, his podcast, Gillette Health podcast, and his instagram, Kyle Gillettemd. He practices in Kansas City, Kansas. We're talking about testosterone. So we were talking about some of the things that testosterone, low testosterone could cause. How about Alzheimer's? Is there a greater risk of Alzheimer's or dementia with low testosterone?
[00:48:48] Speaker A: There's a correlation between neurodegenerative disease, which is basically different types of dementia with low testosterone, but the correlation is more with low total testosterone. If you have a high shbg, that's actually also a correlation. So maybe with low free testosterone as well. But again, we don't know if it's directly caused by that, or if it's just the same process. For example, if a patient has untreated sleep apnea and diabetes for years, that's a much stronger risk factor. And that patient is very likely to have low testosterone happenstance independent of their diabetes. In fact, Alzheimer's is sometimes called type three diabetes because it's such a strong risk factor.
There is certainly that correlation. And you can make the case that preventing diabetes from occurring and also preventing from being in diabetic range, blood glucoses is the best thing that you can do for your overall cognitive plus physical health.
And replacing testosterone for those who are low and for those that don't have contraindications, especially the more strict contraindications, not that there's a perfectly, not that there's a huge, you know, there's always a balance, the scale you're weighing up all the benefits and all the risks.
But for patients that you do replace, it can help prevent diabetes from occurring, and it can help diabetics to be in a better range, especially if they augment that with diet and exercise changes, including resistance training.
[00:50:25] Speaker C: And this testosterone caused prostate testosterone replacement cause prostate cancer, or does it actually prevent prostate cancer?
[00:50:34] Speaker A: It does not cause prostate cancer. I listened to doctor Abraham in one of the previous episodes, and as he correctly pointed out, there's a lot of other risk factors other than testosterone levels that are much stronger risk factors for prostate cancer. About 50% of men by age 80 have a low grade prostate cancer, which is graded by something called gleason scores, and then about 80% or even 90% by age 90 or 100.
The ratio of your estrogen receptor, specifically the eRA and ERB estrogen receptor is a big risk factor for prostate cancer. And a lot of that is genetic. And theres a lot of other genes that put you at risk of prostate cancer earlier in life or more aggressive.
Androgens certainly grow prostate cancers. So whenever I have that, I have a lot of comments even from physicians that say androgens dont grow prostate cancers. They do. Estrogens usually grow breast cancers, but not always. But androgens do grow prostate cancers. However, the intracellular environment in the prostate is much more important than your blood tests. For example, you can have really low testosterone level in your blood, but that type three five alpha reductase enzyme inside the cell, the prostate, could be so active that almost all androgen that's coming in is converted to something that's basically jet fuel for that prostate cancer.
[00:51:59] Speaker C: Yeah. For the listeners out there, I did a two part podcast with doctor Abraham Morgenteller. So if you're interested, go back and listen to that. How about cardiovascular disease? We know there's a lot of different types of cardiovascular disease, but in general, does taking testosterone replacement cause cardiovascular disease?
[00:52:17] Speaker A: It does not appear to cause cardiovascular disease, specifically ischemic cardiovascular disease, but it does increase your risk of what I call electrical cardiovascular disease, according to some studies. So one, any androgen, even having high normal androgen levels, can increase the stickiness of the platelets. So that's something that you want to have a balance of.
Now, your platelets have a normal level of stickiness. People that we have to castrate again for prostate cancer actually have less sticky platelets, and they can bleed too much. So theres a balance. And then it also, again increases that sympathetic input. That same thing that increases your risk of sleep apnea without body composition changes is going to slightly increase your risk, not statistically significantly, but maybe clinically significantly, of Afib and other non fatal arrhythmias. This is based on the traverse trial, but theres other trials that have shown an electrical heart disease risk as well. This is also dose dependent, depending again on your ratio of dht to testosterone to weaker androgens.
The stronger the androgen, the stronger the fight or flight input on the heart. Your cookie cutter protocol of 200 or even 300 milligrams of testosterone every one to two weeks is not likely to be optimal for getting the benefits of having a nice even level. And it has a big spike where you're more likely to have that arrhythmia risk. However, it does not appear that patients, even at very high risk, had any more strokes or heart attacks on testosterone replacement.
[00:53:46] Speaker C: So we have gels as replacement. We have injections, we have pellets. Tell me, pros and cons of each one.
[00:53:54] Speaker A: Yeah, there's a brand name gel, and it's a sustained release, so it's released more over 24 hours. Of course, it's designed to be absorbed through the skin so it can transfer to, you know, children or wives. So that's one of the main downsides of gels. There's also creams which are not extended release, which are only compounded. There's no brand name, but those have a much higher peak and then a much lower crash, which can be used to augment or even mimic natural production, which there's not really a need to mimic natural production, but some people do like to do that. And then also there's more variety. It's not a commercial product, so usually compounded creams can have a lot of more variability. So I do not like creams, partly just for that reason. Pellets have about a 10% extrusion rate, which means they fall out usually within the first couple days. Um, and then also, uh, the way I think about pellets is subcutaneous injections have all the benefits of the pellet with much less of the downsides. So if you need to change the dose, you're probably not going to take out a pellet, you're probably just going to wait. And then if you need to increase the dose, you're probably not going to do an entire another trocar, which is like a huge needle to put a pellet in. So for that reason, I like subcutaneous testosterone. There is brand name subcutaneous testosterone enanthate, but you can also use generics. And instead of doing it intramuscularly, you can just use a very small insulin needle, something like a 27 gauge, which is tiny, and teach people to inject twice a week at home, which is the optimal way for most males and for most females. You also convert to less DHT, so less patients end up needing five alpha reductase inhibitors, which are decreasing the conversion to DHT. So it prevents the pharmaceutical cascade, if you will.
[00:55:33] Speaker C: When did you decide who's going to go on testosterone therapy? Do you do it by number? Do you do it by symptoms plus number? How do you decide?
[00:55:43] Speaker A: Only when they're an appropriate age. Just kidding. There's no appropriate age.
And each individual patient, I do my best to listen to him or her and see what is important to them. If theyre in a profession, even if its from a cognitive standpoint where theyre not going to be sleeping much, maybe theyre doing a lot of shift work, maybe they have lots of small children and they just temporarily want to go on and then naturally optimize in the future. We know we can get them back to 99% of the time. You can go back to your previous production. If youre menopausal or Andrew Pasal and you have very low levels to start, youll go back to those very low levels, most likely.
[00:56:20] Speaker C: And what number do people usually feel the best at? 1000 1208 hundred. And what number do they feel the best at with free testosterone?
[00:56:30] Speaker A: Doctor Justin with normal levels of DHT and with a mid normal shBg, which again affects the metabolism and the ratio of total to free. Most females feel best with a total testosterone between about 31 hundred and sometimes higher. If their DHT is low or their SHBG is high, which happens in a lot of females and then most males feel best with a total between about 551,000. But again, sometimes much higher if they're on things that decrease DHT. I think of it as an androgen pool. So you're mixing your strong androgens. DHT is much more than five times stronger than testosterone in most tissues and even stronger than that in other tissues. So you're mixing that, just like if you're mixing a drink, you don't want to take ten shots of vodka. Again, I don't have a better analogy.
You want to have an adequate level of testosterone. If you have no DHT around whatsoever, then you're going to need more of the wine, if you will, to make up for that content.
[00:57:35] Speaker C: Women that have high sex bonding globulin hormone that are very high, and they go on testosterone, should they try to lower that naturally first instead of going on testosterone? Or could they still go on testosterone with a high sex bonding globulin hormone?
[00:57:51] Speaker A: Yeah.
If they're not able to improve their androgen synthesis, then they're probably not going to decrease SHBG significantly unless they can switch from a ketogenic diet to a different diet. So if there's low testosterone production, often they're better. If they're perimenopausal and certainly menopausal, then they're not going to somehow naturally improve their testosterone levels. The adrenals plus the ovaries, if it's already low, are less likely to have a good increase in output at that point.
[00:58:23] Speaker C: Doctor Khalid Jalette, you're an amazing person. A wealth of information. If people want to find out more about you, how can they do it? Where should they go?
[00:58:31] Speaker A: Thank you on all platforms. I am Gillette Health on Instagram kylejillettemd and our podcast is the Gillette Health podcast. Thank you for having me.
[00:58:40] Speaker C: I really appreciate it. This was a tremendous show and I really, really thank you for being on the open your eyes podcast with Doctor Kerry Gelt and the open your eyes radio show.
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